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1

Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers

Jiménez-González, Concepción, Poechlauer, Peter, Broxterman, Quirinus B., Yang, Bing-Shiou, am Ende, David, Baird, James, Bertsch, Carl, Hannah, Robert E., Dell’Orco, Phil, Noorman, Henk, Yee, Sandy,

Journal:

Organic Process Research & Development

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

2

Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance

Alina Shapira, Yoav D. Livney, Henk J. Broxterman, Yehuda G. Assaraf

Journal:

Drug Resistance Updates

Year:

2011

Language:

english

File:

PDF, 1.38 MB

english, 2011

3

Predictive biomarkers in renal cell cancer: Insights in drug resistance mechanisms

van der Mijn, Johannes C., Mier, James W., Broxterman, Henk J., Verheul, Henk M.

Journal:

Drug Resistance Updates

Year:

2014

Language:

english

File:

PDF, 1.22 MB

english, 2014

4

A functional bioassay to determine the activity of anti-VEGF antibody therapy in blood of patients with cancer

Wentink, Madelon Q, Broxterman, Henk J, Lam, Siu W, Boven, Epie, Walraven, Maudy, Griffioen, Arjan W, Pili, Roberto, van der Vliet, Hans J, de Gruijl, Tanja D, Verheul, Henk M W

Journal:

British Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 532 KB

english, 2016

5

Characterisation of pectin-xylan complexes in tomato primary plant cell walls

Broxterman, Suzanne E., Schols, Henk A.

Journal:

Carbohydrate Polymers

Year:

2018

Language:

english

File:

PDF, 592 KB

english, 2018

6

MRP is frequently expressed in human lung-cancer cell lines, in non-small-cell lung cancer and in normal lung

Giuseppe Giaccone, Jannette van Ark-Otte, Gonzalo J. Rubio, Adi F. Gazdar, Henk J. Broxterman, Anne-Marie C. Dingemans, Marcel J. Flens, Rik J. Scheper, Herbert M. Pinedo

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 1011 KB

english, 1996

7

Identification of novel drug resistance–associated proteins by a panel of rat monoclonal antibodies

Marcel J. Flens, George L. Scheffer, Paul van der Valk, Henk J. Broxterman, Elisabeth W.H.M. Eijdems, Anita C.L.M. Huysmans, Miguel A. Izquierdo, Rik J. Scheper

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 290 KB

english, 1997

8

ChemInform Abstract: Asymmetric Borane Reduction Using Mixtures of Homochiral Amino Alcohol Ligands.

Bernard Kaptein, Henk Elsenberg, Adriaan J. Minnaard, Quirinus B. Broxterman, Lumbertus A. Hulshof, Jan Koek, Ton R. Vries

Journal:

Year:

1999

File:

PDF, 27 KB

1999

9

Novel multiparameter flow cytometry assay using Syto16 for the simultaneous detection of early apoptosis and apoptosis-corrected P-glycoprotein function in clinical samples

Marjolein A. van der Pol, Henk J. Broxterman, Guus Westra, Gert J. Ossenkoppele, Gerrit J. Schuurhuis

Journal:

Cytometry Part B: Clinical Cytometry

Year:

2003

Language:

english

File:

PDF, 160 KB

english, 2003

10

Daunorubicin efflux against a concentration gradient in non-P-glycoprotein multidrug-resistant lung-cancer cells

H. Sipko Mülder, Jan Lankelma, Henk Dekker, Henk J. Broxterman, Herbert M. Pinedo

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 948 KB

english, 1994

11

Proteomics of the TRAP-induced platelet releasate

Sander R. Piersma, Henk J. Broxterman, Muhammed Kapci, Richard R. de Haas, Klaas Hoekman, Henk M.W. Verheul, Connie R. Jiménez

Journal:

Journal of Proteomics

Year:

2009

Language:

english

File:

PDF, 765 KB

english, 2009

12

Dutch resolution of racemic 4-hydroxy- and 4-fluorophenylglycine with mixtures of phenylglycine and (+)-10-camphorsulfonic acid

Bernard Kaptein, Henk Elsenberg, Reinier F.P Grimbergen, Quirinus B Broxterman *, Lumbertus A Hulshof, Kees L Pouwer, Ton R Vries

Journal:

Tetrahedron: Asymmetry

Year:

2000

Language:

english

File:

PDF, 3.69 MB

english, 2000

13

Asymmetric borane reduction using mixtures of homochiral amino alcohol ligands

Bernard Kaptein, Henk Elsenberg, Adriaan J Minnaard, Quirinus B Broxterman *, Lumbertus A Hulshof, Jan Koek, Ton R Vries

Journal:

Tetrahedron: Asymmetry

Year:

1999

Language:

english

File:

PDF, 110 KB

english, 1999

14

Transporter molecules in multidrug resistance

Rik J. Scheper, George L. Scheffer, Marcel J. Flens, Paul Valk, Henk J. Broxterman, Miguel A. Izquierdo

Journal:

Year:

1996

Language:

english

File:

PDF, 321 KB

english, 1996

15

Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer

Astrid A.M. van der Veldt, Laura Vroling, Richard R. de Haas, Pieter Koolwijk, Alfons J.M. van den Eertwegh, John B.A.G. Haanen, Victor W.M. van Hinsbergh, Henk J. Broxterman, Epie Boven

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 1.34 MB

english, 2012

16

Contribution of chronic hypoxia and circulating endothelial colony forming cells to angiogenesis

Laura Vroling, Pieter Koolwijk, Henk Broxterman, Victor W.M. van Hinsbergh

Journal:

Vascular Pharmacology

Year:

2012

Language:

english

File:

PDF, 62 KB

english, 2012

17

A doxorubicin–CNGRC-peptide conjugate with prodrug properties

Yvette van Hensbergen, Henk J. Broxterman, Yvonne W. Elderkamp, Jan Lankelma, Judith C.C. Beers, Marc Heijn, Epie Boven, Klaas Hoekman, Herbert M. Pinedo

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 508 KB

english, 2002

18

P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines: Evidence for a saturation of active daunorubicin transport

Ellen C. Spoelstra, Henk Dekker, Gerrit Jan Schuurhuis, Henricus J. Broxterman, Jan Lankelma

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.12 MB

english, 1991

19

Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells

Carolien H.M. Versantvoort, Henk J. Broxterman, Jan Lankelma, Nicole feller, Herbert M. Pinedo

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.08 MB

english, 1994

20

Editorial

Nafsika Georgopapadakou, Henk Broxterman, Eric Arts, John Perfect, Steve Ward

Journal:

Drug Resistance Updates

Year:

2004

Language:

english

File:

PDF, 39 KB

english, 2004

21

New cancer therapeutics: target-specific in, cytotoxics out?

Henk J Broxterman, Nafsika H Georgopapadakou

Journal:

Drug Resistance Updates

Year:

2004

Language:

english

File:

PDF, 113 KB

english, 2004

22

Anticancer therapeutics: “Addictive” targets, multi-targeted drugs, new drug combinations

Henk J. Broxterman, Nafsika H. Georgopapadakou

Journal:

Drug Resistance Updates

Year:

2005

Language:

english

File:

PDF, 356 KB

english, 2005

23

Eight years of Drug Resistance Updates

Nafsika Georgopapadakou, Henk Broxterman, Eric Arts, John Perfect, Steve Ward

Journal:

Drug Resistance Updates

Year:

2005

Language:

english

File:

PDF, 45 KB

english, 2005

24

A message from the New Editor-in-Chief: Drug Resistance Updates—The past and the future

Christian G. Giske, Henk J. Broxterman

Journal:

Drug Resistance Updates

Year:

2010

Language:

english

File:

PDF, 75 KB

english, 2010

25

Anticancer therapeutics: A surge of new developments increasingly target tumor and stroma

Henk J. Broxterman, Nafsika H. Georgopapadakou

Journal:

Drug Resistance Updates

Year:

2007

Language:

english

File:

PDF, 326 KB

english, 2007

26

Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib

Henk J. Broxterman, Kristy J. Gotink, Henk M.W. Verheul

Journal:

Drug Resistance Updates

Year:

2009

Language:

english

File:

PDF, 433 KB

english, 2009

27

Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-κB-mediated increase of intracellular doxorubicin accumulation

Jens van Wijngaarden, Ermond van Beek, Gerda van Rossum, Chris van der Bent, Klaas Hoekman, Gabri van der Pluijm, Marjolein A. van der Pol, Henk J. Broxterman, Victor W.M. van Hinsbergh, Clemens W.G.M

Journal:

European Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 514 KB

english, 2007

28

Resistance to cytotoxic and anti-angiogenic anticancer agents: similarities and differences

Henk J Broxterman, Jan Lankelma, Klaas Hoekman

Journal:

Drug Resistance Updates

Year:

2003

Language:

english

File:

PDF, 286 KB

english, 2003

29

Editorial

Nafsika Georgopapadakou, Henk Broxterman, Alan Cowman, Eric Arts, David Warnock

Journal:

Drug Resistance Updates

Year:

2002

Language:

english

File:

PDF, 20 KB

english, 2002

30

Editorial for Vol. 6, Issue 1

Nafsika Georgopapadakou, Henk Broxterman, Eric Arts, John Perfect, Alan Cowman

Journal:

Drug Resistance Updates

Year:

2003

Language:

english

File:

PDF, 28 KB

english, 2003

31

Editorial

Nafsika H. Georgopapadakou, Henk Broxterman, Henry Chambers, Alan F. Cowman, Mark Wainberg

Journal:

Drug Resistance Updates

Year:

1998

Language:

english

File:

PDF, 261 KB

english, 1998

32

89th Annual Meeting of the American Association for Cancer research (AACR): New Orleans, LA, USA 28 March–1 April 1998

Henk J. Broxterman, Nafsika H. Georgopapadakou

Journal:

Drug Resistance Updates

Year:

1998

Language:

english

File:

PDF, 199 KB

english, 1998

33

Direct activation of caspases by RGD-peptides may increase drug sensitivity of tumour cells

Henk J. Broxterman, Klaas Hoekman

Journal:

Drug Resistance Updates

Year:

1999

Language:

english

File:

PDF, 114 KB

english, 1999

34

EDITORIAL

Nafsika H. Georgopapadakou, Henk Broxterman, Henry Chambers, Alan F. Cowman, Mark Wainberg

Journal:

Drug Resistance Updates

Year:

1999

Language:

english

File:

PDF, 60 KB

english, 1999

35

EDITORIAL

Nafsika Georgopapadakou, Henk Broxterman, Alan Cowman, Daniel Kuritzkes, David Warnock

Journal:

Drug Resistance Updates

Year:

2001

Language:

english

File:

PDF, 68 KB

english, 2001

36

Cancer research 2001: drug resistance, new targets and drug combinations

Henk J. Broxterman, Nafsika Georgopapadakou

Journal:

Drug Resistance Updates

Year:

2001

Language:

english

File:

PDF, 202 KB

english, 2001

37

In vivo voltammetric investigations into the action of HA-966 on central dopaminergic neurons

Jan Mos, Henk J. Broxterman, Wouter P. Van Bennekom

Journal:

Year:

1981

Language:

english

File:

PDF, 316 KB

english, 1981

38

Cross-tolerance of dopamine metabolism to baclofen, γ-butyrolactone and HA-966 in the striatum and olfactory tubercle of the rat

Henk J. Broxterman, Erik L. Noach, Cees F.M. van Valkenburg, Amerentia Wijling

Journal:

Year:

1981

Language:

english

File:

PDF, 524 KB

english, 1981

39

Evidence for daunomycin efflux from multidrug-resistant 2780AD human ovarian carcinoma cells against a concentration gradient

Jan Lankelma, Ellen C. Spoelstra, Henk Dekker, Henricus J. Broxterman

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1990

Language:

english

File:

PDF, 461 KB

english, 1990

40

P-glycoprotein-independent decrease in drug accumulation by phorbol ester treatment of tumor cells

Peter R Wielinga, Marc Heijn, Henk J Broxterman, Jan Lankelma

Journal:

Biochemical Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.04 MB

english, 1997

41

Cancer research 2000: drug resistance, new targets and drugs in development

Henk J. Broxterman, Nafsika Georgopapadakou

Journal:

Drug Resistance Updates

Year:

2000

Language:

english

File:

PDF, 164 KB

english, 2000

42

Asymmetric Strecker Synthesis of α-Amino Acids via a Crystallization-Induced Asymmetric Transformation Using ( R )-Phenylglycine Amide as Chiral Auxiliary

Boesten, Wilhelmus H. J., Seerden, Jean-Paul G., de Lange, Ben, Dielemans, Hubertus J. A., Elsenberg, Henk L. M., Kaptein, Bernard, Moody, Harold M., Kellogg, Richard M., Broxterman, Quirinus B.

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 59 KB

english, 2001

43

Cross-resistance to clinically used tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib

Gotink, Kristy J., Rovithi, Maria, de Haas, Richard R., Honeywell, Richard J., Dekker, Henk, Poel, Dennis, Azijli, Kaamar, Peters, Godefridus J., Broxterman, Henk J., Verheul, Henk M. W.

Journal:

Cellular Oncology

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

44

Evaluation of different phospho-tyrosine antibodies for label-free phosphoproteomics

van der Mijn, Johannes C., Labots, Mariette, Piersma, Sander R., Pham, Thang V., Knol, Jaco C., Broxterman, Henk J., Verheul, Henk M., Jiménez, Connie R.

Journal:

Journal of Proteomics

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

45

Angiogenesis Inhibitors. Drug Selectivity and Target Specificity

Kesisis, Georgios, Broxterman, Henk, Giaccone, Giuseppe

Journal:

Current Pharmaceutical Design

Year:

2007

Language:

english

File:

PDF, 283 KB

english, 2007

46

Multidrug resistance proteins and other drug transport-related resistance to natural product agents

Broxterman, Henk J., Giaccone, Giuseppe, Lankelma, Jan

Journal:

Current Opinion in Oncology

Year:

1995

File:

PDF, 848 KB

1995

47

Sunitinib activates Axl signaling in renal cell cancer

van der Mijn, Johannes C., Broxterman, Henk J., Knol, Jaco C., Piersma, Sander R., De Haas, Richard R., Dekker, Henk, Pham, Thang V., Van Beusechem, Victor W., Halmos, Balazs, Mier, James W., Jiménez,

Journal:

International Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 626 KB

english, 2016

48

Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer

van der Mijn, Johannes C., Sol, Nik, Mellema, Wouter, Jimenez, Connie R., Piersma, Sander R., Dekker, Henk, Schutte, Lisette M., Smit, Egbert F., Broxterman, Henk J., Skog, Johan, Tannous, Bakhos A.,

Journal:

Journal of Extracellular Vesicles

Year:

2014

Language:

english

File:

PDF, 1.49 MB

english, 2014

49

Acetylated pectins in raw and heat processed carrots

Broxterman, Suzanne E., Picouet, Pierre, Schols, Henk A.

Journal:

Carbohydrate Polymers

Year:

2017

Language:

english

File:

PDF, 882 KB

english, 2017

50

Interactions between pectin and cellulose in primary plant cell walls

Broxterman, Suzanne E., Schols, Henk A.

Journal:

Carbohydrate Polymers

Year:

2018

Language:

english

File:

PDF, 723 KB

english, 2018